GSK3 Function in the Brain during Development, Neuronal Plasticity, and Neurodegeneration
Figure 1
Modulation of GSK3 activity by phosphorylation. Protein phosphatases 1 and 2A activate GSK3 by removing Ser9/21 phosphorylation. It has also been reported that phosphorylation in tyrosine residues by members of the receptor tyrosine kinase family of cell surface receptors (RTKs) or by autophosphorylation may activate GSK3. On the other hand, signaling networks activate several protein kinases, which may bring about phosphorylation of different residues and inhibition of GSK3.
