Cerebrospinal Fluid Biomarkers in Idiopathic Normal Pressure Hydrocephalus

Table 4

Correlations between CSF biomarkers.

	NFL	t-Tau	A𝛽1-42	p-Tau181	TNF-α	TGFβ1
Age	−0.112 (0.52)	0.383* (0.023)	0.215 (0.22)	0.010 (0.95)	0.246 (0.15)	−0.009 (0.96)
NFL		0.030 (0.86)	−0.225 (0.19)	0.063 (0.71)	0.130 (0.46)	−0.013 (0.94)
t-Tau	0.030 (0.86)		−0.071 (0.69)	0.667* (<0.001)	0.143 (0.41)	0.413* (0.014)
A𝛽1-42	−0.225 (0.19)	−0.071 (0.69)		−0.169 (0.33)	−0.024 (0.89)	−0.103 (0.56)
p-Tau181	0.063 (0.71)	0.667* (<0.001)	−0.169 (0.33)		−0.138 (0.43)	0.205 (0.24)
TNF-α	0.130 (0.46)	0.143 (0.41)	−0.024 (0.89)	−0.138 (0.43)		0.267 (0.12)
TGFβ1	−0.013 (0.94)	0.413* (0.014)	−0.103 (0.56)	0.205 (0.24)	0.267 (0.12)

NFL: neurofilament light chain, t-tau: total tau, p-tau₁₈₁: phosphorylated tau₁₈₁, A𝛽₄₂: amyloid-𝛽_1-42, TNF-α: tumour necrosis factor-α, and TGFβ1: transforming growth factor β1.