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International Journal of Alzheimer’s Disease
Volume 2011 (2011), Article ID 347569, 9 pages
http://dx.doi.org/10.4061/2011/347569
Research Article

Centella asiatica Attenuates D-Galactose-Induced Cognitive Impairment, Oxidative and Mitochondrial Dysfunction in Mice

Pharmacology Division, University Institute of Pharmaceutical Sciences, UGC Center for Advanced Studies, Panjab University, Chandigarh-160014, India

Received 1 November 2010; Accepted 26 January 2011

Academic Editor: Cesare Mancuso

Copyright © 2011 Anil Kumar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. R. Troen, “The biology of aging,” Mount Sinai Journal of Medicine, vol. 70, no. 1, pp. 3–22, 2003. View at Google Scholar · View at Scopus
  2. N. A. Crivello, I. H. Rosenberg, G. E. Dallal, D. Bielinski, and J. A. Joseph, “Age-related changes in neutral sphingomyelin-specific phospholipase C activity in striatum, hippocampus, and frontal cortex: implication for sensitivity to stress and inflammation,” Neurochemistry International, vol. 47, no. 8, pp. 573–579, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Navarro, M. J. Sánchez Del Pino, C. Gómez, J. L. Peralta, and A. Boveris, “Behavioral dysfunction, brain oxidative stress, and impaired mitochondrial electron transfer in aging mice,” American Journal of Physiology, vol. 282, no. 4, pp. R985–R992, 2002. View at Google Scholar · View at Scopus
  4. L. A. Kaplan and A. J. Pesce, Clinical Chemistry, Mosby, St. Louis, Mo, USA, 3rd edition, 1996.
  5. H. M. Hsieh, W. M. Wu, and M. L. Hu, “Soy isoflavones attenuate oxidative stress and improve parameters related to aging and Alzheimer's disease in C57BL/6J mice treated with d-galactose,” Food and Chemical Toxicology, vol. 47, no. 3, pp. 625–632, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. XU. Song, M. Bao, D. Li, and Y. M. Li, “Advanced glycation in D-galactose induced mouse aging model,” Mechanisms of Ageing and Development, vol. 108, no. 3, pp. 239–251, 1999. View at Publisher · View at Google Scholar · View at Scopus
  7. J. W. Baynes, “The role of AGEs in aging: causation or correlation,” Experimental Gerontology, vol. 36, no. 9, pp. 1527–1537, 2001. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Takeuchi and S. I. Yamagishi, “Possible involvement of advanced glycation end-products (AGEs) in the pathogenesis of Alzheimer's disease,” Current Pharmaceutical Design, vol. 14, no. 10, pp. 973–978, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Kumar, S. Dogra, and A. Prakash, “Effect of carvedilol on behavioral, mitochondrial dysfunction, and oxidative damage against d-galactose induced senescence in mice,” Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 380, no. 5, pp. 431–441, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. A. W. Linnane, S. Marzuki, T. Ozawa, and M. Tanaka, “Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases,” The Lancet, vol. 1, no. 8639, pp. 642–645, 1989. View at Google Scholar · View at Scopus
  11. D. Harman, “Aging: a theory based on free radical and radiation chemistry,” Journal of gerontology, vol. 11, no. 3, pp. 298–300, 1956. View at Google Scholar · View at Scopus
  12. T. Ozawa, “Genetic and functional changes in mitochondria associated with aging,” Physiological Reviews, vol. 77, no. 2, pp. 425–464, 1997. View at Google Scholar · View at Scopus
  13. P. V. Sharma, Dravyaguna Vignana, Chaukhamba Publications Vishwa Bharati Academy, New Delhi, India, 13th edition, 1999.
  14. M. H. V. Kumar and Y. K. Gupta, “Effect of different extracts of Centella asiatica on cognition and markers of oxidative stress in rats,” Journal of Ethnopharmacology, vol. 79, no. 2, pp. 253–260, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. N. D. De Souza, V. Shah, P. D. Desai, P. K. Inamdar, A. D’Sa, and R. Ammonamanchi, “2,3,23-trihydroxy-urs-12-ene and its derivatives, processes for their preparation and their use,” European Patent., 383 171 A2, 1990.
  16. I. Mook-Jung, JI. E. Shin, H. S. Yun et al., “Protective effects of asiaticoside derivatives against beta-amyloid neurotoxicity,” Journal of Neuroscience Research, vol. 58, no. 3, pp. 417–425, 1999. View at Publisher · View at Google Scholar · View at Scopus
  17. K. G. Mohandas Rao, S. Muddanna Rao, and S. Gurumadhva Rao, “Centella asiatica (L.) leaf extract treatment during the growth spurt period enhances hippocampal CA3 neuronal dendritic arborization in rats,” Evidence-Based Complementary and Alternative Medicine, vol. 3, no. 3, pp. 349–357, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. K. G. Mohandas Rao, S. Muddanna Rao, and S. Gurumadhva Rao, “Enhancement of amygdaloid neuronal dendritic arborization by fresh leaf juice of Centella asiatica (Linn) during growth spurt period in rats,” Evidence-Based Complementary and Alternative Medicine, vol. 6, no. 2, pp. 203–210, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. S. B. Rao, M. Chetana, and D. P. Uma, “Centella asiatica treatment during postnatal period enhances learning and memory in mice,” Physiology and Behavior, vol. 86, no. 4, pp. 449–457, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Hussin, A. Abdul-Hamid, S. Mohamad, N. Saari, M. Ismail, and M. H. Bejo, “Protective effect of Centella asiatica extract and powder on oxidative stress in rats,” Food Chemistry, vol. 100, no. 2, pp. 535–541, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Kumar, A. Prakash, and S. Dogra, “Naringin alleviates cognitive impairment, mitochondrial dysfunction and oxidative stress induced by d-galactose in mice,” Food and Chemical Toxicology, vol. 48, no. 2, pp. 626–632, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Kumar, S. Dogra, and A. Prakash, “Neuroprotective effects of Centella asiatica against intracerebroventricular colchicine—induced cognitive impairment and oxidative stress,” International Journal of Alzheimer's Disease, vol. 2009, Article ID 972178, 8 pages, 2009. View at Google Scholar
  23. A. C. Sharma and S. K. Kulkarni, “Evaluation of learning and memory mechanisms employing elevated plus-maze in rats and mice,” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 16, no. 1, pp. 117–125, 1992. View at Google Scholar · View at Scopus
  24. B. Berman and G. Hastings, “Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria: implications for Parkinson's disease,” Journal of Neurochemistry, vol. 63, pp. 1185–1195, 1997. View at Google Scholar
  25. T. E. King, “Preparations and properties of soluble NADH dehydrogenases from cardiac muscle,” Methods in Enzymology, vol. 10, pp. 275–294, 1967. View at Publisher · View at Google Scholar
  26. T. E. King, “Preparation of succinate dehydrogenase and reconstitution of succinate oxidase,” Methods in Enzymology, vol. 10, pp. 322–331, 1967. View at Publisher · View at Google Scholar
  27. Y. Liu, D. A. Peterson, H. Kimura, and D. Schubert, “Mechanism of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide (MTT) reduction,” Journal of Neurochemistry, vol. 69, no. 2, pp. 581–593, 1997. View at Google Scholar · View at Scopus
  28. E. D. Wills, “Mechanisms of lipid peroxide formation in animal tissues,” Biochemical Journal, vol. 99, no. 3, pp. 667–676, 1966. View at Google Scholar · View at Scopus
  29. L. C. Green, D. A. Wagner, and J. Glogowski, “Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids,” Analytical Biochemistry, vol. 193, pp. 265–275, 1982. View at Google Scholar · View at Scopus
  30. G. L. Ellman, “Tissue sulfhydryl groups,” Archives of Biochemistry and Biophysics, vol. 82, no. 1, pp. 48670–48677, 1959. View at Google Scholar · View at Scopus
  31. Y. Kono, “Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase,” Archives of Biochemistry and Biophysics, vol. 186, no. 1, pp. 189–195, 1978. View at Google Scholar · View at Scopus
  32. H. Luck, “Catalase,” in Methods of Enzymatic Analysis, H. U. Bergmeyer, Ed., pp. 885–893, Academic Press, New York, NY, USA, 1971. View at Google Scholar
  33. W. H. Habig and W. B. Jakoby, “Assays for differentiation of glutathione S-transferases,” Methods in Enzymology, vol. 77, pp. 398–405, 1981. View at Google Scholar · View at Scopus
  34. G. L. Ellman, K. D. Courtney, V. Andres, and R. M. Featherstone, “A new and rapid colorimetric determination of acetylcholinesterase activity,” Biochemical Pharmacology, vol. 7, no. 2, pp. 88–95, 1961. View at Google Scholar · View at Scopus
  35. A. G. Gornall, C. T. Bardawill, and M. M. David, “Determination of serum proteins by means of Biuret reaction,” The Journal of Biological Chemistry, vol. 177, pp. 751–766, 1949. View at Google Scholar
  36. X. U. Cui, P. Zuo, Q. Zhang et al., “Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-α-lipoic acid,” Journal of Neuroscience Research, vol. 84, no. 3, pp. 647–654, 2006. View at Publisher · View at Google Scholar · View at Scopus
  37. S. C. Ho, J. H. Liu, and R. Y. Wu, “Establishment of the mimetic aging effect in mice caused by D-galactose,” Biogerontology, vol. 4, no. 1, pp. 15–18, 2003. View at Publisher · View at Google Scholar · View at Scopus
  38. Y. U. X. Shen, S. Y. Xu, W. Wei et al., “Melatonin reduces memory changes and neural oxidative damage in mice treated with D-galactose,” Journal of Pineal Research, vol. 32, no. 3, pp. 173–178, 2002. View at Publisher · View at Google Scholar · View at Scopus
  39. S. Ya-Zhen, M. Gong, Z. Xiao-Xia, W. Bao-Yuan, and L. Su-Ting, “Improving effects of SSF on memory deficits and pathological changes of neural and immunological systems in senescent mice,” Acta Pharmacologica Sinica, vol. 22, no. 12, pp. 1078–1083, 2001. View at Google Scholar · View at Scopus
  40. H. Wei, L. Li, Q. Song, H. Ai, J. Chu, and W. Li, “Behavioural study of the D-galactose induced aging model in C57BL/6J mice,” Behavioural Brain Research, vol. 157, no. 2, pp. 245–251, 2005. View at Publisher · View at Google Scholar · View at Scopus
  41. S. Z. Zhong, Q. H. Ge, R. Qu, Q. Li, and S. P. Ma, “Paeonol attenuates neurotoxicity and ameliorates cognitive impairment induced by d-galactose in ICR mice,” Journal of the Neurological Sciences, vol. 277, no. 1-2, pp. 58–64, 2009. View at Publisher · View at Google Scholar · View at Scopus
  42. F. Pallotti, X. I. Chen, E. Bonilla, and E. A. Schon, “Evidence that specific mtDNA point mutations may not accumulate in skeletal muscle during normal human aging,” American Journal of Human Genetics, vol. 59, no. 3, pp. 591–602, 1996. View at Google Scholar · View at Scopus
  43. G. Cortopassi and E. Wang, “Modelling the effects of age-related mtDNA mutation accumulation; Complex I deficiency, superoxide and cell death,” Biochimica et Biophysica Acta, vol. 1271, no. 1, pp. 171–176, 1995. View at Publisher · View at Google Scholar · View at Scopus
  44. J. Long, X. Wang, H. Gao et al., “D-Galactose toxicity in mice is associated with mitochondrial dysfunction: protecting effects of mitochondrial nutrient R-alpha-lipoic acid,” Biogerontology, vol. 8, no. 3, pp. 373–381, 2007. View at Publisher · View at Google Scholar · View at Scopus
  45. J. F. Turrens, “Superoxide production by the mitochondrial respiratory chain,” Bioscience Reports, vol. 17, no. 1, pp. 3–8, 1997. View at Publisher · View at Google Scholar · View at Scopus
  46. M. K. Zainol, A. Abdul-Hamid, S. Yusof, and R. Muse, “Anti-oxidative activity and total polyphenolic compounds of leaf, root and petiole of four accessions of Centella asiatica (L.) urban,” Food Chemistry, vol. 81, pp. 575–581, 2003. View at Google Scholar