Centella asiatica Attenuates D-Galactose-Induced Cognitive Impairment, Oxidative and Mitochondrial Dysfunction in Mice

Table 2

Effect of Centella asiatica (CA; 150 and 300 mg/kg, p.o.) on memory performance in elevated plus maze paradigm in D-galactose-treated mice.

Treatment (mg/ Kg)	Day 20 (ITL)	Day 21 (1st RTL)	Day 42 (2nd RTL)
Naïve	77.5 ± 2.4	15.0 ± 2.7	10.0 ± 2.5
D-gal (100)	77.6 ± 2.3	87.8 ± 2.6^a	84.3 ± 2.3^a
CA (300)	79.8 ± 2.6	13.5 ± 2.4	11.0 ± 2.2
CA (150) + D-gal (100)	78.3 ± 2.7	50.6 ± 2.6^b	47.0 ± 2.5^b
CA (300) + D-gal (100)	79.0 ± 2.6	40.8 ± 2.6^b,c	38.0 ± 2.3^b,c

The initial acquisition latencies (IAL) on day 20 and retention latencies on days 21 (1st RL) and 42 (2nd RL) following AlCl₃ concurrent treatment were observed. Values are mean ± S.E.M. ^a𝑃<.05 as compared to naive group; ^b𝑃<.05 as compared to D-gal-treated group; ^c𝑃<.05 as compared to CA (150) + D-gal group (repeated measures two-way ANOVA followed by Tukey’s test for multiple comparisons).