Association Study of Genetic Variants in CDKN2A/CDKN2B Genes/Loci with Late-Onset Alzheimer's Disease

Table 2

CDKN2A/B polymorphisms: genotype, allele frequencies, and unadjusted odds ratios (OR) and corresponding 95% confidence intervals (CI) for 238 Late-Onset Alzheimer’s Disease (LOAD) cases and 250 controls.

	LOAD^a no. (%)	Controls no. (%)	𝜒^2 (df, P-value)	unadjusted OR (95% CI)
Total	238	250
CDKN2A
Rs 11515
Genotypes			3.47 (2,  .17)
CC	169 (71)	163 (65.2)		1^b
CG	62 (26)	72 (28.8)		0.83 (0.54–1.27)
GG	7 (3)	15 (6)		0.45 (0.16–1.21)
Alleles			3.20 (1,   .07)
C	400 (84)	398 (79)		1^b
G	76 (16)	102 (21)		0.74 (0.53–1.04)
Rs 3731246
Genotypes			1.13 (2,  .56)
GG	183 (76.9)	182 (72.8)		1^b
GC	50 (21)	61 (24.4)		0.82 (0.52–1.28)
CC	5 (2.1)	7 (2.8)		0.71 (0.19–2.55)
Alleles			1.17 (1,  .27)
G	416 (87.4)	425 (85)		1^b
C	60 (12.6)	75 (15)		0.82 (0.56–1.2)
Rs 3731211
Genotypes			0.57 (2,  .75)
TT	105 (44.1)	106 (42.4)		1^b
AT	99 (41.6)	112 (44.8)		0.89 (0.60–1.33)
AA	34 (14.3)	32 (12.8)		1.07 (0.59–1.93)
Alleles			0.00 (1,  .96)
T	309 (64.9)	324 (64.8)		1^b
A	167 (35.1)	176 (35.2)		0.99 (0.76–1.31)
CDKN2B
Rs 598664
Genotypes			1.11 (2,  .57)
AA	182 (74.5)	181 (72.4)		1^b
AG	51 (21.4)	62 (24.8)		0.82 (0.52–1.28)
GG	5 (2.1)	7 (2.8)		0.71 (0.19–2.55)
Alleles			1.15 (1,  .28)
A	415 (87.2)	424 (84.8)		1^b
G	61 (12.8)	76 (15.2)		1.35 (0.89–2.07)

^aLOAD cases were defined by the occurrence of Alzheimer’s disease with an onset age ≥65 years.
^bReference category.