E22Δ Mutation in Amyloid <i>β</i>-Protein Promotes <i>β</i>-Sheet Transformation, Radical Production, and Synaptotoxicity, But Not Neurotoxicity

<table>Aggregation profiles of E22Δ-A<i>β</i>40 and E22Δ-A<i>β</i>42 (25 <i>μ</i>M) after incubation at 37°C. (a) Sedimentation assay estimated by HPLC analysis after centrifugation. (b) Th-T fluorescence assay. °, A<i>β</i>42; △, A<i>β</i>40; ●, E22Δ-A<i>β</i>42; ▲, E22Δ-A<i>β</i>40. (c) Western blotting without incubation.</table>

International Journal of Alzheimer’s Disease

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Figure 1

Figure 1: E22Δ Mutation in Amyloid <i>β</i>-Protein Promotes <i>β</i>-Sheet Transformation, Radical Production, and Synaptotoxicity, But Not Neurotoxicity 

International Journal of Alzheimer’s Disease

E22Δ Mutation in Amyloid β-Protein Promotes β-Sheet Transformation, Radical Production, and Synaptotoxicity, But Not Neurotoxicity

Figure 1