Deconstructing GSK-3: The Fine Regulation of Its Activity

Table 1

GSK-3 substrates.

Metabolic proteins	Structural proteins	Transcription factors
Glycogen synthase	Tau	AP-1
ATP cytrate lyase	MAP1B	𝛽-catenin
PKA	MAP2	CREB
PDH	NCAM	C/EBP
Acetyl-CoA carboxylase	Neurofilaments	Myc
PP1	CRMP2	NFκB
PP2A inhibitor	Dynein	NFAT
PP2A	Dynamin-like protein	GR
Cyclin D1	MBP	HSF-1
eIF2B	APC	Notch
NGF receptor	Kinesin light chain	p53
Axin		HIF-1
APP
Bax
VDAC
Hexokinase
Presenilin
LRP5/6