Cerebrospinal Fluid Levels of sAPPα and sAPPβ in Lewy Body and Alzheimer's Disease: Clinical and Neurochemical Correlates

Table 3

Correlations between CSF analytes and MMSE score.

	MMSE	Aβ38	Aβ40	Aβ42	Tau	P-Tau^†	sAppβ
All diagnoses together (total group 𝑛=107)
sAppα	0.206*	0.337**	0.291**	0.220*	0.285**	0.411**	0.876**
sAppβ	0.384**	0.295**	0.549**	0.233*	0.074	0.329**	—
Tau	−0.241*	0.718**	0.001	0.193	—	—	0.113
P-Tau	0.133	0.488**	0.259*	−0.103	—	—	0.329**
NC (𝑛=12)
sAppα	−0.059	0.622*	0.497	0.643*	0.286	0.357; Obs; 𝑛=7	0.865**
sAppβ	0.018	0.658*	0.616*	0.515	0.214	0.429; 𝑛=7	—
Tau	0.386	0.464	0.393	0.429	—	—	0.214
P-Tau	−0.540	0.964**	0.821*	0.857**	—	—	0.429
AD (𝑛=50)
sAppα	0.179	0.071	0.009	−0.093	0.146	0.570**; 𝑛=31	0.811**
sAppβ	0.422**	−0.123	0.395**	−0.168	−0.154	0.340; 𝑛=31	—
Tau	−0.579**	0.723**	−0.371**	0.330*	NR	NR	−0.154
P-Tau	0.107	0.454*	0.148	−0.132	—	—	0.340
LBD (𝑛=45)
sAppα	0.289	0.537**	0.430**	0.417**	0.428**	0.252	0.927**
sAppβ	0.371*	0.663**	0.608**	0.498**	0.446**	0.274	—
Tau	0.234	0.675**	0.629**	0.362*	—	—	0.446*
P-Tau	0.255	0.510**	0.431**	0.134	—	—	0.274
DLB(𝑛=24)
sAppα	0.297	0.481*	0.461*	0.359 𝑃=0.09	0.377	0.408	0.930**
sAppβ	0.314	0.527**	0.600**	0.401 𝑃=0.058	0.274	0.299	—
Tau	0.156	0.581**	0.471*	0.185	—	—	0.274
P-Tau	0.422	0.421	0.211	−0.060	—	—	0.299
PDD (𝑛=21)
sAppα	0.300	0.593**	0.456*	0.542*	0.483*	0.185	0.902**
sAppβ	—	0.791**	0.641**	0.644**	0.618**	0.312	—
Tau	0.249	0.809**	0.850**	0.565**	NR	NR	0.618**
P-Tau	0.110	0.624**	0.792**	0.315	NR	NR	0.312

Spearman correlation. Numbers represent ρ values. *Correlation is significant at the 0.05 level, **correlation is significant at the 0.01 level. NR = no relevance. ^†P-Tau: incomplete data (total 𝑛=78).