Figure 4: Immune-related genes: Alzheimer’s disease susceptibility genes returned from very large genomewide association studies are in black, and those from the pre-GWAS era in grey. Binding interactions are indicated by linked diamonds and other effects by arrows. Borr: Borrelia burgdorferi; C. Pneu: chlamydia pneumoniae; Cytomeg: cytomegalovirus; H. Pyl: Helicobacter pylori; P. Ging: Porphyromonas gingivalis; IgE: immunoglobulin E, Sialic: alpha2-3- or alpha2-6-linked sialic acids: the genes in the top right square were returned from GWAS prior to the very large studies. black star: Herpes simplex: see text for details.