International Journal of Alzheimer’s Disease / 2011 / Article / Tab 4

Review Article

Diagnostic Utility of CSF Tau and A 𝜷 𝟒 𝟐 in Dementia: A Meta-Analysis

Table 4

Effect size, its 95% CI, and % weight calculations for each selected study of CSF A in Alzheimer’s disease and dementia due to other causes.

S. no.Author’s name and year Country where the studies were conducted Aβ42 level (pg/mL) (AD and control) Effect size (pg/mL)95% CIWeight Aβ 42 level (pg/mL) (DOC and control) Effect size (pg/mL)95% CIWeight
DiseasedControlDiseasedControl
N SDN SDRMD+SEN SDN SDRMD+SE

1Galasko et al. (1998) [17]USA82833379601485473−652.00074.031−797.10–−506.900.012741129464601485473−356.00081.475−515.69–−196.310.011
2Kanai et al. (1998) [19]Japan32109.973.241242180−132.10030.947−192.75–−71.450.0693320918041242180−33.00042.096−115.51–−49.510.041
3Andreasen et al. (2001) [7]Sweden10552318018897242−374.00059.684−490.98–−257.020.0192370432118897242−193.00087.941−365.36–−20.640.009
4Sjögren et al. (2002) [20]Sweden194119917853161−442.00045.173−530.54–−353.460.033156809617853161−173.00046.251−263.65–−82.350.034
5Grossman et al. (2005) [21]USA175415.11395.229.7−41.2009.015−58.87–−23.530.819134414.11395.229.7−51.2009.118−69.07–−33.330.876
6de Jong et al. (2006) [22]The Netherlands6141912830869207−450.00041.193−530.74–−369.260.0392565522030869207−214.00058.003−327.68–−100.3270.022
7Bibl et al. (2007) [23]Germany153109015810320−500.00085.829−668.22–−331.780.0091548022015810320−330.000100.266−526.52–−133.480.007

*Mean in diseased group, **Mean in control group and raw mean difference.

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