Lack of Association between the GPR3 Gene and the Risk for Alzheimer's Disease

Table 2

Nucleotide variants in GPR3 promoter and coding regions and their allele frequencies in AD patients and controls.

		Allele frequencies
SNP	position	AD	CNT	P value
g.27718954A>G	Upstream 5′ end	0.084	0.082	1.0
g.27719102A>T	Upstream 5′ end	0.084	0.082	1.0
c.51C>A	Exon 2	0.026	0.023	.84
c.771C>T	Exon 2	0.011	0.010	.89

The g.27718953A>G (rs2504785) and g.27719102A>T SNPs are in the genomic region (NC_000001.10) upstream of GPR3 exon1 and probably linked in a haplotype (AA or GT). The c.51C>A and c.771C>T (NM_05821.2) are synonymous SNPs and correspond to Rs11586015 and Rs2230880, respectively. SNP: single nucleotide polymorphism; AD: Alzheimer’s disease patients; CNT: controls.