Correlation of Copper Interaction, Copper-Driven Aggregation, and Copper-Driven H2O2 Formation with Aβ40 Conformation
Figure 4
The binding affinity of Cu2+ to Aβ40 peptide in (a) 5% TFE and (b) 40% TFE measured by tyrosine fluorescence spectroscopy. Insets in (a) and (b) show the Jot plot. The concentration of Aβ40 was 10 μM. The solid lines represent the fitting curve using the equation as depicted in Section 2 with . The values in (a) and (b) are all >0.96, and the values are <0.05.
