Recent Development of Bifunctional Small Molecules to Study Metal-Amyloid-β Species in Alzheimer's Disease

Figure 3

Overview of the two rational structure-based design strategies currently used to develop small molecules having bifunctionality (metal chelation and Aβ interaction). The first approach is based on the connection of metal chelation and Aβ recognition structural moieties (Approach I: linkage). The second approach is direct incorporation of a metal chelation site into an Aβ interacting framework (Approach II: incorporation).