The Pathogenesis of Alzheimer's Disease: A Reevaluation of the “Amyloid Cascade Hypothesis”

<table>The original Amyloid Cascade Hypothesis (ACH) [<a href="/journals/ijad/2011/630865/#B7">7</a>]. A<i>β</i>: <i>β</i>-amyloid, APOE: apolipoprotein E, APP: amyloid precursor protein, <i>PSEN1/2</i>: <i>presenilin  genes  1  and  2</i>, NFTs: neurofibrillary tangles.</table>

International Journal of Alzheimer’s Disease

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Figure 2: The Pathogenesis of Alzheimer's Disease: A Reevaluation of the “Amyloid Cascade Hypothesis” 