Evidence for Elevated Cerebrospinal Fluid ERK1/2 Levels in Alzheimer Dementia

Table 1

Demographical data, MMSE scores, and classical CSF biomarkers*.

		AD	MCI-AD	MCI-stable	ND
	𝑛	33	21	25	16
Age (years)	Mean	68.4	66	69	63.3
	SD	7.6	8.5	7.4	8.4
Gender	m/f	15/18	7/14	10/15	6/10
MMSE	Mean	19 (𝑛=29)	26.3	26	27.3 (𝑛=9)
	SD	4.8	1.3	2.5	2.3
tTau (pg/mL)	Median	609.8	536.5	210	185.5
	25%–75% percentile	372.6–1023	432.2–611.5	145–349.4	176.9–236.6
pTau (pg/mL)	Median	106	84	50	45.2
	25%–75% percentile	67.5–129.0	73.1–100.3	35.0–66.6	37.2–57.3
Aβ42 (pg/mL)	Median	432	397.2	745	794.5
	25%–75% percentile	361.5–523.6	344.8–553.2	589.3–981.5	635.8–844.8

*The CSF levels of tTau, pTau, and Aβ42 are shown here for comparative purposes. The actual measurements were performed within the context of other studies, and some of the data have been published before [13, 16–18].