Evidence for Elevated Cerebrospinal Fluid ERK1/2 Levels in Alzheimer Dementia
Table 2
Analysis for correlations between ERK1/2 and classical biomarkers*.
ERK1/2
Patients group
CSF marker
value
value summary
Whole sample ()#
Aβ 1-42
−0.436
< 0.0001
Significant
t-Tau
0.404
0.0001
Significant
p-Tau
0.384
0.0003
Significant
Age
0.0001
0.999
n.s.
ND ()#
Aβ 1-42
−0.0242
0.9346
n.s.
t-Tau
−0.174
0.5528
n.s.
p-Tau
−0.0022
0.9941
n.s.
Age
0.0726
0.8052
n.s.
MCI-stable ()#
Aβ 1-42
0.0947
0.6912
n.s.
t-Tau
0.399
0.0816
n.s.
p-Tau
0.433
0.0563
n.s.
Age
0.0845
0.7231
n.s.
MCI-AD ()#
Aβ 1-42
−0.0992
0.6772
n.s.
t-Tau
0.325
0.1623
n.s.
p-Tau
0.0248
0.9173
n.s.
Age
0.171
0.4723
n.s.
AD ()#
Aβ 1-42
−0.544
0.0013
Significant
t-Tau
0.176
0.3343
n.s.
p-Tau
0.161
0.3789
n.s.
Age
−0.136
0.457
n.s.
*Spearman correlation coefficients (r) and values (two tailed) are indicated. #ERK1/2 measurements below LLOD () were excluded from the correlation analysis.
