Research Article
Genetic Association between Akt1 Polymorphisms and Alzheimer's Disease in a Japanese Population
Table 1
Genotypic frequencies of SNPs of the Akt1 gene.
| SNP | Location | Genotype | AD | Controls | value | HWE value |
| | | A/A | 3 | 3 | | | rs113021411 | intron 1 | A/C | 33 | 45 | 0.002* | AD: 0.93 | | | C/C | 142 | 81 | | Controls: 0.68 | | | C/C | 77 | 22 | | |
| rs2494746 | intron 3 | C/G | 72 | 85 | 0.00002* | AD: 0.52 | | | G/G | 29 | 22 | | Controls: 0.04* | | | C/C | 78 | 22 | | |
| rs2494743 | intron 3 | C/T | 71 | 85 | 0.00001* | AD: 0.47 | | | T/T | 29 | 22 | | Controls: 0.04* | | | A/A | 27 | 20 | | |
| rs2494738 | intron 3 | A/G | 79 | 68 | 0.3 | AD: 0.93 | | | G/G | 71 | 41 | | Controls: 0.91 | | | A/A | 174 | 126 | | |
| rs3730344 | intron 6 | A/G | 4 | 3 | 0.99 | AD: 0.99 | | | G/G | 0 | 0 | | Controls: 0.99 | | | A/A | 151 | 114 | | |
| rs7140735 | intron 13 | A/G | 27 | 13 | 0.17 | AD: 0.88 | | | G/G | 0 | 1 | | Controls: 0.99 |
|
|
: Statistically significant (Fisher's exact probabilities test).
|