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International Journal of Alzheimer’s Disease
Volume 2011, Article ID 786264, 7 pages
http://dx.doi.org/10.4061/2011/786264
Research Article

Feasibility of Predicting MCI/AD Using Neuropsychological Tests and Serum β-Amyloid

Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA

Received 13 October 2010; Revised 23 March 2011; Accepted 27 March 2011

Academic Editor: Katsuya Urakami

Copyright © 2011 Cheryl A. Luis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We examined the usefulness of brief neuropsychological tests and serum Aβ as a predictive test for detecting MCI/AD in older adults. Serum Aβ levels were measured from 208 subjects who were cognitively normal at enrollment and blood draw. Twenty-eight of the subjects subsequently developed MCI (n=18) or AD (n=10) over the follow-up period. Baseline measures of global cognition, memory, language fluency, and serum Aβ1–42 and the ratio of serum Aβ1–42/Aβ1–40 were significant predictors for future MCI/AD using Cox regression with demographic variables, APOE ε4, vascular risk factors, and specific medication as covariates. An optimal sensitivity of 85.2% and specificity of 86.5% for predicting MCI/AD was achieved using ROC analyses. Brief neuropsychological tests and measurements of Aβ1–42 obtained via blood warrants further study as a practical and cost effective method for wide-scale screening for identifying older adults who may be at-risk for pathological cognitive decline.