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International Journal of Alzheimer’s Disease
Volume 2011, Article ID 786264, 7 pages
http://dx.doi.org/10.4061/2011/786264
Research Article

Feasibility of Predicting MCI/AD Using Neuropsychological Tests and Serum β-Amyloid

Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA

Received 13 October 2010; Revised 23 March 2011; Accepted 27 March 2011

Academic Editor: Katsuya Urakami

Copyright © 2011 Cheryl A. Luis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Brookmeyer, E. Johnson, K. Ziegler-Graham, and H. M. Arrighi, “Forecasting the global burden of Alzheimer's disease,” Alzheimer's and Dementia, vol. 3, no. 3, pp. 186–191, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. D. L. Weimer and M. A. Sager, “Early identification and treatment of Alzheimer's disease: social and fiscal outcomes,” Alzheimer's and Dementia, vol. 5, no. 3, pp. 215–226, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. C. Holmes, D. Boche, D. Wilkinson et al., “Long-term effects of Abeta42 immunisation in Alzheimer’s disease: follow-up of a randomized, placebo-controlled phase 1 trial,” Lancet, vol. 372, pp. 216–223, 2008. View at Google Scholar
  4. D. Blacker, H. Lee, A. Muzikansky et al., “Neuropsychological measures in normal individuals that predict subsequent cognitive decline,” Archives of Neurology, vol. 64, no. 6, pp. 862–871, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. M. W. Bondi, D. P. Salmon, D. Galasko, R. G. Thomas, and L. J. Thal, “Neuropsychological function and apolipoprotein E genotype in the preclinical detection of Alzheimer's disease,” Psychology and Aging, vol. 14, no. 2, pp. 295–303, 1999. View at Publisher · View at Google Scholar · View at Scopus
  6. H. Amieva, M. Le Goff, X. Millet et al., “Prodromal Alzheimer's disease: successive emergence of the clinical symptoms,” Annals of Neurology, vol. 64, no. 5, pp. 492–498, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. G. W. Small, A. La Rue, S. Komo, A. Kaplan, and M. A. Mandelkern, “Predictors of cognitive change in middle-aged and older adults with memory loss,” American Journal of Psychiatry, vol. 152, no. 12, pp. 1757–1764, 1995. View at Google Scholar · View at Scopus
  8. W. E. Klunk, H. Engler, A. Nordberg et al., “Imaging brain amyloid in Alzheimer's disease with pittsburgh compound-B,” Annals of Neurology, vol. 55, no. 3, pp. 309–319, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. G. W. Small, V. Kepe, L. M. Ercoli et al., “PET of brain amyloid and tau in mild cognitive impairment,” New England Journal of Medicine, vol. 355, no. 25, pp. 2652–2663, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. P. Vemuri, H. J. Wiste, S. D. Weigand et al., “MRI and CSF biomarkers in normal, MCI, and AD subjects: predicting future clinical change,” Neurology, vol. 73, no. 4, pp. 294–301, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. A. M. Fagan, C. M. Roe, C. Xiong, M. A. Mintun, J. C. Morris, and D. M. Holtzman, “Cerebrospinal fluid tau/β-amyloid (42) ratio as a prediction of cognitive decline in nondemented older adults,” Archives of Neurology, vol. 64, no. 3, pp. 343–349, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. N. R. Graff-Radford, J. E. Crook, J. Lucas et al., “Association of low plasma Aβ42/Aβ40 ratios with increased imminent risk for mild cognitive impairment and Alzheimer' disease,” Archives of Neurology, vol. 64, no. 3, pp. 354–362, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. O. I. Okereke, W. Xia, D. J. Selkoe, and F. Grodstein, “Ten-year change in plasma amyloid β levels and late-life cognitive decline,” Archives of Neurology, vol. 66, no. 10, pp. 1247–1253, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. L. Abdullah, C. Luis, D. Paris et al., “Serum Aβ levels as predictors of conversion to mild cognitive impairment/Alzheimer disease in an ADAPT subcohort,” Molecular Medicine, vol. 15, no. 11-12, pp. 432–437, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. R. J. Bateman, G. Wen, J. C. Morris, and D. M. Holtzman, “Fluctuations of CSF amyloid-β levels: implications for a diagnostic and therapeutic biomarker,” Neurology, vol. 68, no. 9, pp. 666–669, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. L. Abdullah, D. Paris, C. Luis et al., “The influence of diagnosis, intra- and inter-person variability on serum and plasma Aβ levels,” Neuroscience Letters, vol. 428, no. 2-3, pp. 53–58, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. D. R. Lachno, H. Vanderstichele, G. De Groote et al., “The influence of matrix type, diurnal rhythm and sample collection and processing on the measurement of plasma beta-amyloid isoforms using the INNO-BIA plasma Abeta forms multiplex assay,” The Journal of Nutrition, Health and Aging, vol. 13, pp. 220–225, 2009. View at Google Scholar
  18. N. Ertekin-Taner, L. H. Younkin, D. M. Yager et al., “Plasma amyloid β protein is elevated in late-onset Alzheimer' disease families,” Neurology, vol. 70, no. 8, pp. 596–606, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. P. W. Thompson and A. Lockhart, “Monitoring the amyloid beta-peptide in vivo—caveat emptor,” Drug Discovery Today, vol. 14, no. 5-6, pp. 241–251, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. C. Meinert , L. McCaffrey, and J. Breitner, “Alzheimer's disease anti-inflammatory prevention trial: design, methods and baseline results,” Alzheimer’s Dement, vol. 5, pp. 93–104, 2009. View at Google Scholar
  21. E. L. Teng and H. C. Chui, “The modified mini-mental state (MMS) examination,” Journal of Clinical Psychiatry, vol. 48, no. 8, pp. 314–318, 1987. View at Google Scholar · View at Scopus
  22. J. Brandt and R. Benedict, “The Hopkins verbal learning test: development of a new memory test with six equivalent forms,” Clinical Neuropsychologist, vol. 5, no. 2, pp. 125–142, 1991. View at Google Scholar · View at Scopus
  23. D. Wechsler, Wechsler Adult Intelligence Scale—Revised. Manual, Psychological Corporation, New York, NY, USA, 1981.
  24. B. Wilson, J. Cockburn, A. Baddeley, and R. Hiorns, “The development and validation of a test battery for detecting and monitoring everyday memory problems,” Journal of Clinical and Experimental Neuropsychology, vol. 11, no. 6, pp. 855–870, 1989. View at Google Scholar · View at Scopus
  25. R. Benedict, C. Schrectlen, L. Groninger et al., “Revision of the brief visual spatial memory tests: studies of normal performance, reliability and validity,” Psychological Assessment, vol. 10, pp. 31–39, 1996. View at Google Scholar
  26. M. F. Folstein, S. E. Folstein, and P. R. McHugh, “Mini mental state. A practical method for grading the cognitive state of patients for the clinician,” Journal of Psychiatric Research, vol. 12, no. 3, pp. 189–198, 1975. View at Publisher · View at Google Scholar · View at Scopus
  27. J. Yesavage, T. Brink, T. Rose et al., “Development and validation of a geriatric depression screening scale: a preliminary report,” Journal of Psychiatric Research, vol. 17, pp. 37–49, 1983. View at Google Scholar
  28. L. Squire, C. Wetzel, and P. Slater, “Memory complaints after electroconvulsive therapy: assessment with a new self-rating scale instrument,” Biological Psychiatry, vol. 14, pp. 791–801, 1979. View at Google Scholar
  29. C. M. Clark and D. C. Ewbank, “Performance of the dementia severity rating scale: a caregiver questionnaire for rating severity in Alzheimer' disease,” Alzheimer Disease and Associated Disorders, vol. 10, no. 1, pp. 31–39, 1996. View at Publisher · View at Google Scholar · View at Scopus
  30. C. A. de Jager, A. C. M. C. Schrijnemaekers, T. E. M. Honey, and M. M. Budge, “Detection of MCI in the clinic: evaluation of the sensitivity and specificity of a computerised test battery, the Hopkins verbal learning test and the MMSE,” Age and Ageing, vol. 38, no. 4, pp. 455–460, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. C. A. Luis, L. Abdullah, D. Paris et al., “Serum β-amyloid correlates with neuropsychological impairment,” Aging, Neuropsychology, and Cognition, vol. 16, no. 2, pp. 203–218, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. J. T. Tschanz, K. A. Welsh-Bohmer, I. Skoog et al., “Dementia diagnoses from clinical and neuropsychological data compared: the cache county study,” Neurology, vol. 54, no. 6, pp. 1290–1296, 2000. View at Google Scholar · View at Scopus
  33. J. C. Morris, A. Heyman, R. C. Mohs et al., “The consortium to establish a registry for Alzheimer's disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease,” Neurology, vol. 39, no. 9, pp. 1159–1165, 1989. View at Google Scholar · View at Scopus
  34. D. Wechsler, Wechsler Memory Scale—Revised, Psychological Corporation, San Antonio, Tex, USA, 1987.
  35. A. Benton, K. Hamsher, and A. Siven, Multilingual Aphasia Examination, AJA Associates, Iowa City, Calif, USA, 3rd edition, 1994.
  36. S. W. Sumerall, P. L. Timmons, A. L. James, M. J. M. Ewing, and M. E. Oehlert, “Expanded norms for the controlled oral word association test,” Journal of Clinical Psychology, vol. 53, no. 5, pp. 517–521, 1997. View at Publisher · View at Google Scholar · View at Scopus
  37. R. Reitan, Trail Making Test: Manual for Administering and Scoring, Reitan Neuropsychological Laboratory, Tucson, Ariz, USA, 1986.
  38. A. Smith, Symbol Digit Modalities Test—Manual, Western Psychological Services, Los Angeles, Calif, USA, 1982.
  39. R. Zachary, Shipley Institute of Living Scale—Revised, Western Psychological Services, Los Angeles, Calif, USA, 1991.
  40. G. McKhann, D. Drachman, M. Folstein et al., “Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer's disease,” Neurology, vol. 34, pp. 939–944, 1984. View at Google Scholar
  41. R. C. Petersen, G. E. Smith, S. C. Waring, R. J. Ivnik, E. G. Tangalos, and E. Kokmen, “Mild cognitive impairment: clinical characterization and outcome,” Archives of Neurology, vol. 56, no. 3, pp. 303–308, 1999. View at Google Scholar · View at Scopus
  42. R. C. Petersen, R. Doody, A. Kurz et al., “Current concepts in mild cognitive impairment,” Archives of Neurology, vol. 58, no. 12, pp. 1985–1992, 2001. View at Google Scholar · View at Scopus
  43. J. L. Whitwell, R. C. Petersen, S. Negash et al., “Patterns of atrophy differ among specific subtypes of mild cognitive impairment,” Archives of Neurology, vol. 64, no. 8, pp. 1130–1138, 2007. View at Publisher · View at Google Scholar · View at Scopus
  44. L. Abdullah, C. Luis, D. Paris et al., “High serum Aβ and vascular risk factors in first-degree relatives of Alzheimer's disease patients,” Molecular Medicine, vol. 15, no. 3-4, pp. 95–100, 2009. View at Publisher · View at Google Scholar · View at Scopus
  45. C. G. Lyketsos, J. C. S. Breitner, R. C. Green et al., “Naproxen and celecoxib do not prevent AD in early results from a randomized clinical trial,” Neurology, vol. 68, no. 21, pp. 1800–1808, 2007. View at Publisher · View at Google Scholar · View at Scopus
  46. J. Gunstad, M. B. Spitznagel, E. Glickman et al., “β-amyloid is associated with reduced cognitive function in healthy older adults,” Journal of Neuropsychiatry and Clinical Neurosciences, vol. 20, no. 3, pp. 327–330, 2008. View at Publisher · View at Google Scholar · View at Scopus
  47. S. Cosention, Y. Stern, E. Sokolov et al., “Plasma {beta}-amyloid and cognitive decline,” Archives of Neurology. In press.
  48. K. Yaffe, A. Weston, N. R. Graff-Radford et al., “Association of plasma beta-amyloid level and cognitive reserve with subsequent cognitive decline,” Journal of the American Medical Association, vol. 305, pp. 261–266, 2011. View at Google Scholar
  49. J. C. S. Breitner, “Onset of Alzheimer's dementia occurs commonly without prior cognitive impairment: results from the Alzheimer's disease anti-inflammatory prevention trial (ADAPT),” Alzheimers Dement, vol. 4, no. 4, supplement 1, pp. T130–T131, 2008. View at Google Scholar
  50. N. Mattsson, H. Zetterberg, O. Hansson et al., “CSF biomarkers and incipient Alzheimer' disease in patients with mild cognitive impairment,” Journal of the American Medical Association, vol. 302, no. 4, pp. 385–393, 2009. View at Publisher · View at Google Scholar · View at Scopus