Figure 3: The sequences of the antisense strands of siRNAs used in studies. The guide strand of each siRNA is fully complementary to the mutant (C G) PSEN1 transcript and it has one mismatch (C:C) in respect to the wild type gene. The region between 2nd to 8th nucleotide, counted from the 5′-end of the antisense strand of siRNA is known as the seed region.