Genetics of Late-Onset Alzheimer's Disease: Update from the Alzgene Database and Analysis of Shared Pathways
Table 1
Top-rated genes associated with LOAD.
Gene
Ch
N° minor
Quality (HuGENet)
Caucasian OR
Asian OR
All ethnic groups OR
APOE
19
4,167
AAA
3.77 (3.29–4.32)
3.99 (2.86–5.57)
3.61 (3.20–4.08)
CLU
8
53,712
AAA
0.87 (0.85–0.90)
n.a
0.88 (0.86–0.91)
PICALM
11
44,358
AAA
0.89 (0.86–0.92)
n.a
0.90 (0.86–0.93)
EXOC3L2
19
13,519
AAA
1.17 (1.12–1.23)
n.a
1.17 (1.12–1.23)
BIN1
2
24,713
AAA
1.14 (1.08–1.21)
n.a
1.14 (1.08–1.21)
CR1
1
18,779
AAA
1.14 (1.08–1.20)
n.a
1.16 (1.09–1.22)
SORL1
11
1,734
AAA
1.07 (1.00–1.15)
1.30 (1.13–1.50)
1.10 (1.02–1.17)
TNK1
17
3,538
AAA
0.84 (0.76–0.93)
n.a
0.84 (0.76–0.93)
IL8
4
1,157
AAA
1.26 (1.01–1.58)
n.a
1.26 (1.01–1.58)
LDLR
19
1,228
AAA
0.85 (0.72–0.89)
n.a
0.85 (0.72–0.89)
CST3
20
1,203
AAA
1.28 (1.04–1.56)
n.a
1.23 (1.03–1.48)
CHRNB2
1
227
BAA
0.69 (0.51–0.95)
n.a
0.67 (0.50–0.90)
SORCS1
10
567
BAA
1.34 (1.09–1.65)
n.a
1.34 (1.09–1.65)
TNF
6
301
BAA
n.a
1.37 (1.05–1.79)
1.35 (1.39–1.77)
CCR2
3
308
BAA
0.73 (0.56–0.97)
n.a
0.73 (0.56–0.97)
OR values are referred to the best SNP for each gene. n.a: one study or none; meta-analysis could not be performed. HuGENet classification was used to assess the quality of studies (see text).
