Protein Kinase C-Regulated Aβ Production and Clearance

Figure 3

Schematic summary of role of PKC-MAPK-dependent Aβ production and clearance. PKCα upregulates α-secretase activity while PKCε stimulates Aβ-degrading activity of ECE-1, probably via MAPK-dependent Ets-1 pathway. MAPK is also known to activate α-secretase activity independently or through PKC activation.