Copper Inhibits NMDA Receptor-Independent LTP and Modulates the Paired-Pulse Ratio after LTP in Mouse Hippocampal Slices
Figure 2
Copper inhibited LTP in the CA1 and CA3 regions of mouse hippocampal slices. (a) In the CA1 region, compared to control slices (black circles), LTP was inhibited by copper (open circles). (b) The average of the fEPSP slopes taken one hour after tetanus was significantly decreased from 141.4 ± 10.5% to 86.6 ± 15.7% in copper-treated slices (, ). (c) In the CA1 region, the peak PTP was reduced from % to % in copper-treated slices (, ). (d) Copper-inhibited LTP in the CA3 region of the mouse hippocampus, control groups are indicated by black circles and copper-treated groups are indicated by open circles. (e) The average fEPSP in the CA3 region measured one hour after tetanus was significantly decreased from % to % in copper-treated slices ( ). (f) In the CA3 region, the peak PTP was significantly reduced from % to % in copper-treated slices (, ).
