Copper Inhibits NMDA Receptor-Independent LTP and Modulates the Paired-Pulse Ratio after LTP in Mouse Hippocampal Slices

Figure 5

Copper gradually enhanced the PPR after LTP in the CA1 region. Paired-pulse tests were done at intervals before and after the HFS tetanus (star). Prior to the tetanus, the PPR was not significantly different between control slices (filled circles) and copper-treated slices (open circles). Five minutes after the HFS, there was a decrease in the PPR. The difference in the percent facilitation became statistically significant 60 minutes after the tetanus, at which point the average PPR of the copper group was 150.4±5.1% as compared to 132.7±8.9% in the control group (𝑃=0.007, 𝑛=5).