Copper Inhibits NMDA Receptor-Independent LTP and Modulates the Paired-Pulse Ratio after LTP in Mouse Hippocampal Slices

Figure 6

Zinc blocked LTP but did not change the PPR after LTP in the CA1 region. (a) LTP was present in control slices (filled circles) but was blocked by 5 μM ZnCl₂ (open circles). (b) The magnitude of the LTPs averaged one hour after the tetanus was reduced from 138.0±15.1% to 101.5±13.2% in zinc-treated slices (𝑃=0.013, 𝑛=8). (c) The PPR after the expression of LTP was not affected by zinc (open circles). All slices were tetanized at 𝑡=0 m in this experiment.

(a)

(b)

(c)