Copper Inhibits NMDA Receptor-Independent LTP and Modulates the Paired-Pulse Ratio after LTP in Mouse Hippocampal Slices
Figure 7
CTZ modulated the effect of copper on synaptic plasticity in the CA1 region. (a) Slices treated with CTZ (black circles) and control slices (gray circles) exhibited identical LTP, but LTP was inhibited by copper (open circles) and by copper combined with CTZ (gray squares). (b) The level of LTP was % in control slices (gray bar) () and % in CTZ-treated slices (black bar) (). Copper reduced the LTP to % (white bar), and LTP was further reduced to % in slices treated with copper and CTZ (striped bar) (). (c) There was no significant difference among the PPRs at 30 minutes prior to the tetanus across groups. At 60 minutes after tetanus, there was no change in the PPR in the control group, a significant enhancement in the PPR in the copper group (, ), no significant change in the PPR in the CTZ + copper group, and a significant decrease in the PPR in the CTZ group (, ). The baseline (BL) PPRs measured after 90 minutes without a tetanus was decreased from % at 30 minutes prior to the tetanus to % in slices treated with CTZ (, ). The BL PPRs did not vary among the other groups.
