Fluorescent Analysis of the Cell-Selective Alzheimer's Disease Aβ Peptide Surface Membrane Binding: Influence of Membrane Components
Figure 1
Fluorescence analysis of Aβ-FAM binding on PC12 cells. PC12 cells were exposed to Aβ-FAM for a short period of time (80 min). Based on the levels of intensity of bound Aβ-FAM cells are grouped into three distinct subpopulations: a population of cells that did not bind Aβ (subpopulation A), a population of cells that show a high binding affinity for Aβ (subpopulation B), and a population of cells that show an extra high binding affinity for Aβ (subpopulation C). Fluorescence analysis showed that approximately 62% of all PC12 cells in the culture were classified as Aβ positive (Aβ +).
