Knockdown of BACE1-AS Nonprotein-Coding Transcript Modulates Beta-Amyloid-Related Hippocampal Neurogenesis
Effects of siLNA in BACE1 and BACE1-AS RNAs levels in vivo. To test the ability of siLNAs to affect BACE1 and BACE1-AS in vivo, we inserted a minipump as explained with overlap siLNA (a), BACE1-AS siLNA (b), and BACE1 siLNA (c) during two weeks. LNA-modified siRNAs reduced BACE1 mRNA levels in approximately 60% in each of the brain regions examined. In hippocampus, the protein levels of BACE1 were also clearly reduced (d, duplicates).
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