An Intron 7 Polymorphism in APP Affects the Age of Onset of Dementia in Down Syndrome
Figure 1
Kaplan-Meier survival plot showing the effect of the tetranucleotide attt5–8 upon age of onset of dementia in 103 people with DS. Those people carrying three copies of the attt6 allele of this polymorphism develop dementia with an earlier age of onset than those with any other combination of alleles ().
