Research Article

Thickness in Entorhinal and Subicular Cortex Predicts Episodic Memory Decline in Mild Cognitive Impairment

Table 2

Neuropsychological test performance: MCI and NC subjects scores on individual neuropsychological tests. Averages across specified tests provide Domain scores. Both initial and follow-up raw scores, with standard deviation in parentheses, as well as average scores are provided for both groups.

MCI subjects ( )NC subjects ( )
Initial visit average raw scoreFollow-up visit average raw scoreZ-scaled change over timeInitial visit average raw scoreFollow-up visit average raw scoreZ-scaled change over time

DomainNeuropsychological test

Processing speedWeschler adult intelligence scale-III Digit Symbol59.0 (14.5)54.8 (16.0)−0.19 (1.1)72.2 (14.6)72.6 (19.7)0.28 (0.8)
Trailmaking test part A**36.0 (12.7)36.7 (14.0)−0.01 (1.1)29.3 (7.1)30.5 (9.6)−0.01 (1.0)
Stroop test, word reading speed**50.0 (8.7)51.9 (8.4)−0.21 (1.0)47.5 (5.9)47.7 (8.5)0.28 (1.0)

Average for Processing Speed Domain−0.140.18

Executive functioningBoston naming test letter fluency (F.A.S)39.6 (11.7)35.6 (10.0)−0.39 (0.9)40.0 (9.9)45.6 (9.9)0.46 (1.0)
Boston naming test category fluency (Animal naming)18.3 (4.03)17.0 (4.8)−0.16 (1.0)20.8 (4.0)21.8 (4.5)0.20 (1.0)
Trailmaking test part B**92.9 (47.3)103.8 (47.6)−0.13 (1.1)63.6 (16.9)72.3 (29.8)0.14 (0.9)
Stroop test, Interference (Kaplan version)**135.2 (30.4)148.5 (42.1)−0.28 (1.0)118.3 (31.1)119.1 (34.7)0.39 (0.9)

Average for Executive Functioning Domain−0.240.30

Memory encodingWeschler memory scale-III, logical memory I37.1 (11.9)36.5 (11.4)−0.15 (1.2)44.5 (8.2)45.5 (10.5)0.17 (0.6)
Weschler memory scale-III, verbal paired associates I16.8 (8.5)16.8 (6.9)−0.19 (1.2)23.7 (6.0)24.4 (6.6)0.24 (0.6)
Buschke-Fuld selective reminding test, consistent long-term retrieval48.3 (34.3)36.2 (35.1)−0.35 (0.94)57.3 (32.5)63.4 (34.5)0.39 (0.9)

Average for Memory Encoding Domain−0.230.27

Delayed memoryRey-Osterreith Complex Figure, delayed recall9.9 (4.6)9.2 (6.0)−0.01 (1.0)15.2 (5.7)14.6 (6.7)0.01 (1.0)
Weschler memory scale-III, logical memory II18.4 (9.8)20.8 (10.7)0.07 (1.1)26.9 (7.8)27.3 (8.3)−0.12 (0.8)
Weschler memory scale-III, verbal paired associates II5.1 (2.8)5.7 (2.2)−0.01 (1.3)7.2 (1.5)7.3 (1.4)0.04 (0.6)
Buschke-Fuld selective reminding test, delayed recall5.9 (3.7)5.3 (4.2)−0.10 (1.0)8.2 (2.4)7.8 (3.4)0.14 (1.0)

Average for Delayed Memory Domain0.010.02

**Larger number indicates longer time to complete test, thus poorer performance. -score ± sign is inverted to represent this.