Influence of Water Quality on Cholesterol-Induced Tau Pathology: Preliminary Data

Figure 1

Water quality induced differences in immunohistochemical staining for phosphorylated tau (p-tau, AT8) and amyloid-beta (A𝛽; 10D5) in the brains of cholesterol-fed rabbits compared to animals fed normal control diet. The four groups of rabbits were comprised of female rabbits fed normal rabbit chow and provided local tap water to drink (A1–A4), 1% cholesterol diet and distilled drinking water (B1–B4), 1% cholesterol diet and copper supplemented distilled drinking water (C1–C4), or 1% cholesterol diet and local tap water (D1–D4) for 5 months. Representative p-tau AT8 staining in fascia dentate (A1–D1, 10X), hippocampus (A2–D2, 4X), and superior temporal cortex (A3–D3, 10X—insets 40X), and A𝛽 10D5 staining in superior temporal cortex (A4–D4, 10X) are shown.