Simvastatin Blocks Blood-Brain Barrier Disruptions Induced by Elevated Cholesterol Both In Vivo and In Vitro

Table 1

Concentration of total cholesterol (TC) in the serum, cortex, and hippocampus of rabbits fed a control diet, high-cholesterol diet, and high-cholesterol diet plus simvastatin.

Group	Serum TC	Cortex TC	Hippocampus TC
Control diet	51.4 ± 9.96^b	1.29±0.16	1.36±0.14
Cholesterol diet	1449.6±677.1	1.25±0.13	1.31±0.23
Cholesterol diet + simvastatin	866.1 ± 147.46^a	1.27±0.11	1.38±0.10

The concentration of total serum cholesterol is expressed as g/mL and the concentration of total cortex or hippocampus cholesterol is expressed as g/100 g wet weight of tissue. Data are expressed as means ± S.D. (𝑛=8; ^a𝑃<0.05; ^b𝑃<0.01; compared with Cholesterol diet).