Accumulation of Vesicle-Associated Human Tau in Distal Dendrites Drives Degeneration and Tau Secretion in an In Situ Cellular Tauopathy Model
Somatodendritic cytoskeletal elements in ABCs. (a) Somatodendritic and axonal distribution of cytoskeletal elements in ABCs are shown in transverse sections through ABC somata and dendrites immunostained for total, dynamic, and stably polymerized tubulin with axonal profiles shown in insets (top). The distributions of the major neurofilament protein NF180, a tau-like endogenous MAP, and a mitochondrial marker (COX1) are similarly displayed (bottom). MTs are the dominant dendritic element (especially tyrosinated tubulin-rich MTs in large proximal dendrites), whereas acetylated MTs and NFs predominate in the axon. An endogenous, axonally localized tau-like protein occurs in sea lampreys, but is poorly expressed in ABCs. (b) Mitochondria are typically distributed evenly throughout ABC dendrites and are somewhat more concentrated in axonal profiles (inset). Scale bars: (a) 100 μm, (b) 50 μm, (b) inset 10 μm.
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