Modulation of Gamma-Secretase for the Treatment of Alzheimer's Disease

Figure 6

MALDI-TOF analysis of Aβ peptides from conditioned media of APP-overexpressing CHO cells treated with GSMs. The immunoprecipitated Aβ peptides were subjected to MALDI-TOF analysis to visualize individual Aβ fragments. Using a combination of two Aβ antibodies, 6E10, and 4G8 allows precipitation of full length and N- and C-terminal truncated Aβ peptides.