Japanese Alzheimer’s Disease and Other Complex Disorders Diagnosis Based on Mitochondrial SNP Haplogroups
Figure 2
Associations between Japanese haplogroups and mtSNPs of the 15 individuals with the highest predicted probabilities. The description of the associations between Japanese haplogroups and mtSNPs is based on the phylogenetic tree for macrohaplogroups M and N described in Tanaka et al. [26]. The locus of mtDNA polymorphism (mmm), normal nucleotide (rCRS) at the position mmm (), mtDNA mutation at the same position (), the number of the mtDNA mutations at mmm in individual highest clusters (Y), and the number of the normal nucleotides at mmm in individual highest clusters (X) are expressed as mmm . In 16362 > (9/6), for example, 16362 is the mtDNA locus, T is the normal nucleotide at position 16362, C is the mtDNA mutation at that position, 9 is the number of mtDNA mutations, and 6 is the number of the normal nucleotides. (a) Japanese AD patients, (b) Japanese PD patients, (c) Japanese T2D patients, (d) Japanese T2D patients with angiopathy, (e) Japanese centenarians, (f) Japanese semi-supercentenarians, (g) Japanese non-obese young males, and (h) Japanese obese young males.
