Morphologic and Functional Effects of Gamma Secretase Inhibition on Splenic Marginal Zone B Cells

<table>Marginal zone B cells in mice dosed with RO4929097 for 27 days. For each mouse the percentage of MZ B cells (= IgM<sup>+</sup>/B220<sup>+</sup>/CD21<sup>high</sup>/CD23<sup>low</sup>) in the leukocyte gate is shown. Dots represent individual mice. <b>-</b> = average per group. * = statistically significant difference to vehicle control (<svg height="11.375" id="M18" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>). CspA = cyclosporin A. <svg height="10.925" id="M19" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 36.237499 10.925" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,10.65)"><path d="M495 86q-46 -47 -87 -72.5t-63 -25.5q-43 0 -16 107l49 210q7 34 8 50.5t-3 21t-13 4.5q-35 0 -109.5 -72.5t-115.5 -140.5q-21 -75 -38 -159q-50 -10 -76 -21l-6 8l84 340q8 35 -4 35q-17 0 -67 -46l-15 26q44 44 85.5 70.5t64.5 26.5q35 0 10 -103l-24 -98h2
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</svg>–8 mice/sex/group.</table>

International Journal of Alzheimer’s Disease

fig3

Figure 3

Figure 3: Morphologic and Functional Effects of Gamma Secretase Inhibition on Splenic Marginal Zone B Cells 