Morphologic and Functional Effects of Gamma Secretase Inhibition on Splenic Marginal Zone B Cells
Figure 4
Neutralizing VSV antibodies in mice treated with RO4929097 for 27 days. Neutralizing total Ig (= IgM + IgG) and IgG antibody titers in serum are shown. For each group, average and standard deviation at different time points are shown. * = statistically significant difference to vehicle control () at given time-point. Detection limit of assay was 1 (= 1/40 dilution of serum). Non-vaccinated mice had no detectable VSV neutralizing antibodies in their serum (<1) (not shown). 4–8 mice/sex/group.
