Morphologic and Functional Effects of Gamma Secretase Inhibition on Splenic Marginal Zone B Cells

Table 1

Effects of RO4929097 on absolute numbers of white blood cells, neutrophils, and lymphocytes in male and female rats.

(a) After 13 weeks of treatment

		Males			Females
Dose (mg/kg/day)	WBC	Neutrophils	Lymphocytes	WBC	Neutrophils	Lymphocytes
	(10^9/L)	(10^9/L)	(G/L)	(10^9/L)	(10^9/L)	(10^9/L)
0
N	10	10	10	10	10	10
Mean	5.95	1.23	4.26	3.77	0.55	2.94
SD	1.23	0.42	0.92	0.60	0.20	0.47
0.5
N	10	10	10	10	10	10
Mean	5.65	1.20	4.05	3.68	0.67^#	2.76
SD	1.08	0.39	0.75	0.92	0.12	0.86
1.5
N	10	10	10	9	9	9
Mean	6.31	1.78*	4.01	3.10	1.11**	1.70**
SD	1.39	0.54	1.28	0.85	0.54	0.78
3
N	10	10	10	10	10	10
Mean	6.37	2.95**	2.70**	2.87	1.10	1.51
SD	1.58	1.29	1.17	0.47	0.24	0.47

Jonckheere test: **P ≤ 1%; *1% < P ≤ 5%.
U test: P ≤ 1%; ^#1% < P ≤ 5%.
N: number of animals.
SD: standard deviation.

(b) After 6 weeks of recovery

		Males			Females
Dose (mg/kg/day)	WBC	Neutrophils	Lymphocytes	WBC	Neutrophils	Lymphocytes
	(10^9/L)	(10^9/L)	(10^9/L)	(10^9/L)	(10^9/L)	(10^9/L)
0
N	10	10	10	10	10	10
Mean	7.56	1.02	6.19	5.28	0.68	4.36
SD	1.17	0.27	1.18	0.84	0.18	0.76
0.5
N	10	10	10	10	10	10
Mean	7.28	1.07	5.85	5.06	0.68	4.14
SD	1.37	0.25	1.16	1.00	0.17	0.90
1.5
N	10	10	10	10	10	10
Mean	8.40	1.70**	6.25	4.01**	1.28**	2.45**
SD	1.34	0.50	1.25	1.03	0.72	0.81
3
N	10	10	10	10	10	10
Mean	9.13*	3.45**	4.99	3.85**	1.48**	2.08**
SD	2.32	2.10	1.73	0.78	0.54	0.59

Jonckheere test: **P ≤ 1%; *1% < P ≤ 5%.
N: number of animals.
SD: standard deviation.