Review Article
Small-Molecule Inhibitors of GSK-3: Structural Insights and Their Application to Alzheimer's Disease Models
Table 4
Examples of maleimide inhibitors with biological activity against GSK-3, selectivity, X-ray and reference.
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| No. | X | R1 | IC50 (nM) | Kinase panel | In vivo | X-ray | Year/lit. |
| 28 | N | Et | β: 304 | β + 21 | Yes | 1UV5a | 2009 [49] | 29 | CH | Et | β: 92 | β + 2 | Yes | 1UV5a | 2010 [50] | 30 | CH | Me | β: 270 | β + 2 | Yes | 1UV5a | 2010 [50] |
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aDocking studies, PDB code; β: GSK-3β.
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