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International Journal of Alzheimer’s Disease
Volume 2012 (2012), Article ID 512069, 8 pages
Research Article

Automated VOI Analysis in FDDNP PET Using Structural Warping: Validation through Classification of Alzheimer's Disease Patients

1Department of Biomathematics, David Geffen School of Medicine at UCLA, Box 951766, Los Angeles, CA 90095, USA
2Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Box 951735, Los Angeles, CA 90095, USA
3Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA

Received 11 October 2011; Accepted 21 November 2011

Academic Editor: Leonardo Pantoni

Copyright © 2012 Moses Q. Wilks et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We evaluate an automated approach to the cortical surface mapping (CSM) method of VOI analysis in PET. Although CSM has been previously shown to be successful, the process can be long and tedious. Here, we present an approach that removes these difficulties through the use of 3D image warping to a common space. We test this automated method using studies of FDDNP PET in Alzheimer's disease and mild cognitive impairment. For each subject, VOIs were created, through CSM, to extract regional PET data. After warping to the common space, a single set of CSM-generated VOIs was used to extract PET data from all subjects. The data extracted using a single set of VOIs outperformed the manual approach in classifying AD patients from MCIs and controls. This suggests that this automated method can remove variance in measurements of PET data and can facilitate accurate, high-throughput image analysis.