Stimulation-Dependent Intraspinal Microtubules and Synaptic Failure in Alzheimer's Disease: A Review
Figure 1
Redistribution of microtubules in dendritic shafts of hippocampal CA1 neurons after tetanic stimulation during LTP. A relatively small dendrite (about 1200 nm in diameter) of CA1 neurons in a nonstimulated hippocampal slice (a) and (c). Similar size of dendrite of CA1 neurons in a stimulated hippocampal slice (b) and (d). Many subcortical microtubules which went in the direction of spines emerged after stimulation (arrows in (d)). Reprinted from Mitsuyama et al. (2008) [21] with permission. Bar, 200 nm.
