Research Article
Florbetaben PET in the Early Diagnosis of Alzheimer's Disease: A Discrete Event Simulation to Explore Its Potential Value and Key Data Gaps
| Cost item | Value | Unit | Data source |
| Diagnostic work-up | | | | AD+ | $5,120 | Per year | | VaD | $5,885 | Per year | VA VISN 1 and [16–18] | Other non-AD | $6,638 | Per year | | Predementia | $6,187 | Per year | | Imaging and biomarker tests | | | | MRI + MTA | $437 | Per test | | CT + MTA | $300 | Per test | | FDG-PET | $1,042 | Per test | [16], manufacturer | SPECT | $596 | Per test | | CSF | $304 | Per test | | Florbetaben PET | $2,300 | Per test | | Dementia medication | | | | Donepezil | $7.79 | Per day | | Galantamine | $6.36 | Per day | [19] | Rivastigmine | $6.11 | Per day | | Memantine | $7.89 | Per day | | Medical care for predementia | $5,548 | Per year | [20] | Medical care for AD+ | | | | Mild | $8,315 | Per year | | Mildly moderate | $12,806 | Per year | | Moderate | $12,806 | Per year | [20] | Moderately severe | $18,526 | Per year | | Severe | $23,227 | Per year | | Nonmedical care for AD+ | | | | Mild | $154 | Per year | | Mildly moderate | $3,692 | Per year | | Moderate | $12,166 | Per year | [20] | Moderately severe | $14,209 | Per year | | Severe | $23,355 | Per year | | % of additional cost of care for non-AD relative to AD | | | | VaD | 84% | | [21] | Other non-AD | 37% | | Institutional care | $373 | Per day | [22] | Caregiver time | $7.25 | Per hour | [23] | Caregiver burden for predementia | 2.10 | Hours per day | [20] | Caregiver burden for dementia | | | | Mild | 2.10 | Hours per day | | Mildly moderate | 3.58 | Hours per day | | Moderate | 3.58 | Hours per day | [20] | Moderately severe | 3.76 | Hours per day | | Severe | 5.10 | Hours per day | |
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AD: Alzheimer’s disease; VaD: vascular dementia; MRI: magnetic resonance imaging; MTA: medial temporal lobe atrophy; CT: computer tomography; PET: positron emission tomography; FDG: fluorodeoxyglucose; SPECT: single photon emission computer tomography; CSF: cerebral spinal fluid.
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