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International Journal of Alzheimer’s Disease
Volume 2012, Article ID 587215, 6 pages
Review Article

History, Present, and Progress of Frontotemporal Dementia in China: A Systematic Review

1Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
2Neuroscience Research Australia and the University of New South Wales, Randwick, NSW 2052, Australia
3Department of Epidemiology, Public Health School, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
4Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Received 17 October 2011; Accepted 18 January 2012

Academic Editor: Francesco Panza

Copyright © 2012 Ru-Jing Ren et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We aim to provide an overview of clinical and demographical features and neuropathological research on frontotemporal dementia (FTD) from China over the past decade. We reviewed the demographic features, clinical presentations, and neuropathology of the FTD-spectrum disorders from the 49 cases in China published since 1998. On the basis of these findings, we retrospect the history and speculate on future progress in terms of FTD in China. We found that most published papers comprise case reports with a few retrospective studies with small sample sizes. Behavior variant FTD (bvFTD) was the most common diagnostic subtype, of which 35% were associated with amyotrophic lateral sclerosis or Parkinsonian syndrome. More than 47% patients with FTD had age onset before 65. There were no differences in age of onset and sex distribution between diagnostic subtypes. The spectrum of neuropathological diagnosis of bvFTD was frontotemporal lobe degeneration (FTLD) with tau protein or ubiquitin-immunopositive inclusions, and FTLD without intracellular inclusions. Median survival in bvFTD was 14 years. This paper provides an overview of the current status and pointers for future research directions of FTD in China.