𝜸-Secretase-Dependent Proteolysis of Transmembrane Domain of Amyloid Precursor Protein: Successive Tri- and Tetrapeptide Release in Amyloid 𝜷-Protein Production

Figure 4

Multiple cleavage sites on the transmembrane domain of γ-secretase substrates. APP [38], APLP-1 [30, 39], mNotch-1 [40], and CD44 [41].