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International Journal of Alzheimer’s Disease
Volume 2012, Article ID 608013, 7 pages
http://dx.doi.org/10.1155/2012/608013
Clinical Study

Risk and Determinants of Dementia in Patients with Mild Cognitive Impairment and Brain Subcortical Vascular Changes: A Study of Clinical, Neuroimaging, and Biological Markers—The VMCI-Tuscany Study: Rationale, Design, and Methodology

1Department of Neurological and Psychiatric Sciences, University of Florence, Largo Brambilla 3, 50134 Florence, Italy
2Department of Medical and Surgical Critical Care, University of Florence, 50134 Florence, Italy
3Department of Neurosciences, University of Pisa, 56126 Pisa, Italy
4Department of Neurological and Behavioral Sciences, University of Siena, 53100 Siena, Italy
5Radiodiagnostic Section, Department of Clinical Physiopathology, University of Florence, 50134 Florence, Italy

Received 1 December 2011; Revised 16 January 2012; Accepted 16 January 2012

Academic Editor: Kurt A. Jellinger

Copyright © 2012 Anna Poggesi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [17 citations]

The following is the list of published articles that have cited the current article.

  • Mario Mascalchi, Andrea Ginestroni, Nicola Toschi, Anna Poggesi, Paolo Cecchi, Emilia Salvadori, Carlo Tessa, Mirco Cosottini, Nicola De Stefano, Giovanni Pracucci, Leonardo Pantoni, Domenico Inzitari, and Stefano Diciotti, “The burden of microstructural damage modulates cortical activation in elderly subjects with MCI and leuko-araiosis. A DTI and fMRI study,” Human Brain Mapping, 2012. View at Publisher · View at Google Scholar
  • Anna Poggesi, Domenico Inzitari, Leonardo Pantoni, Valentina Rinnoci, Raffaella Valenti, Marco Pasi, Sandro Marini, Emilia Salvadori, Laura Ciolli, Francesca Pescini, Fabio Fierini, Guido Chiti, Serena Nannucci, and Ida Donnini, “The florence VAS-COG Clinic: A model for the care of patients with cognitive and behavioral disturbances consequent to cerebrovascular diseases,” Journal of Alzheimer's Disease, vol. 42, pp. S453–S461, 2014. View at Publisher · View at Google Scholar
  • Anders Wallin, Arto Nordlund, Michael Jonsson, Karin Lind, Åke Edman, Mattias Göthlin, Jacob Stålhammar, Marie Eckerström, Silke Kern, Anne Börjesson-Hanson, Mårten Carlsson, Erik Olsson, Henrik Zetterberg, Kaj Blennow, Johan Svensson, Annika Öhrfelt, Maria Bjerke, Sindre Rolstad, and Carl Eckerström, “The Gothenburg MCI study: design and distribution of Alzheimer’s disease and subcortical vascular disease diagnoses from baseline to 6-year follow-up,” Journal of Cerebral Blood Flow & Metabolism, 2015. View at Publisher · View at Google Scholar
  • Valenti, Salvadori, Poggesi, Ciolli, Pescini, Nannucci, Inzitari, and Pantoni, “Mild cognitive impairment etiologic subtyping using pragmatic and conventional criteria: preliminary experience in the Florence VAS-COG clinic,” Aging Clinical and Experimental Research, vol. 27, no. 3, pp. 345–350, 2015. View at Publisher · View at Google Scholar
  • Emilia Salvadori, Anna Poggesi, Raffaella Valenti, Giovanni Pracucci, Francesca Pescini, Marco Pasi, Serena Nannucci, Sandro Marini, Alessandra Del Bene, Laura Ciolli, Andrea Ginestroni, Stefano Diciotti, Giovanni Orlandi, Ilaria Di Donato, Nicola De Stefano, Mirco Cosottini, Alberto Chiti, Antonio Federico, Maria Teresa Dotti, Ubaldo Bonuccelli, Domenico Inzitari, and Leonardo Pantoni, “Operationalizing mild cognitive impairment criteria in small vessel disease: The vascular mild cognitive impairment-Tuscany study,” Alzheimer's & Dementia, 2015. View at Publisher · View at Google Scholar
  • Stefano Diciotti, Stefano Ciulli, Andrea Ginestroni, Emilia Salvadori, Anna Poggesi, Leonardo Pantoni, Domenico Inzitari, Mario Mascalchi, and Nicola Toschi, “Multimodal MRI classification in vascular mild cognitive impairment,” Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, vol. 2015-, pp. 4278–4281, 2015. View at Publisher · View at Google Scholar
  • Marco Pasi, Anna Poggesi, Emilia Salvadori, Stefano Diciotti, Laura Ciolli, Alessandra Del Bene, Sandro Marini, Serena Nannucci, Francesca Pescini, Raffaella Valenti, Andrea Ginestroni, Nicola Toschi, Mario Mascalchi, Domenico Inzitari, and Leonardo Pantoni, “White matter microstructural damage and depressive symptoms in patients with mild cognitive impairment and cerebral small vessel disease: the VMCI-Tuscany Study,” International Journal of Geriatric Psychiatry, 2015. View at Publisher · View at Google Scholar
  • Marco Pasi, Emilia Salvadori, Anna Poggesi, Laura Ciolli, Alessandra Del Bene, Sandro Marini, Serena Nannucci, Francesca Pescini, Raffaella Valenti, Andrea Ginestroni, Nicola Toschi, Stefano Diciotti, Mario Mascalchi, Domenico Inzitari, and Leonardo Pantoni, “White Matter Microstructural Damage in Small Vessel Disease Is Associated With Montreal Cognitive Assessment But Not With Mini Mental State Examinatio,” Stroke, vol. 46, no. 1, pp. 262–+, 2015. View at Publisher · View at Google Scholar
  • Emilia Salvadori, Anna Poggesi, Giovanni Pracucci, Domenico Inzitari, and Leonardo Pantoni, “Development and Psychometric Properties of a Neuropsychological Battery for Mild Cognitive Impairment with Small Vessel Disease: The VMCI-Tuscany Stud,” Journal Of Alzheimers Disease, vol. 43, no. 4, pp. 1313–1323, 2015. View at Publisher · View at Google Scholar
  • Raffaella Valenti, Marco Pasi, Stefano Diciotti, Alberto Chiti, Domenico Inzitari, Leonardo Pantoni, Alessandra Del Bene, Emilia Salvadori, Giovanni Pracucci, Laura Ciolli, Sandro Marini, Serena Nannucci, Francesca Pescini, Giovanni Orlandi, Mirco Cosottini, Mario Mascalchi, Ubaldo Bonuccelli, Anna Poggesi, and Andrea Ginestroni, “Cerebral microbleeds in patients with mild cognitive impairment and small vessel disease: The Vascular Mild Cognitive Impairment (VMCI)-Tuscany study,” Journal of the Neurological Sciences, vol. 368, pp. 195–202, 2016. View at Publisher · View at Google Scholar
  • Emilia Salvadori, Anna Poggesi, Raffaella Valenti, Eleonora Della Rocca, Stefano Diciotti, Mario Mascalchi, Domenico Inzitari, and Leonardo Pantoni, “The rehabilitation of attention in patients with mild cognitive impairment and brain subcortical vascular changes using the Attention Process Training-II. The RehAtt Study: rationale, design and methodology,” Neurological Sciences, 2016. View at Publisher · View at Google Scholar
  • Zongsheng Chen, Xianfa Liang, Chunxiu Zhang, Jinling Wang, Gaiping Chen, Hong Zhang, and Zhongwu Sun, “Correlation of thyroid dysfunction and cognitive impairments induced by subcortical ischemic vascular disease,” Brain And Behavior, vol. 6, no. 4, 2016. View at Publisher · View at Google Scholar
  • Sudhansu Chokroverty, “Sleep Disorders in the Elderly,” Sleep Disorders Medicine, pp. 1115–1138, 2017. View at Publisher · View at Google Scholar
  • Mario Mascalchi, Stefano Orsolini, Emilia Salvadori, Antonio Giorgio, Nicola Toschi, Andrea Ginestroni, Stefano Diciotti, Leonardo Pantoni, Domenico Inzitari, Stefano Ciulli, Anna Poggesi, and Nicola De Stefano, “Resting state fMRI regional homogeneity correlates with cognition measures in subcortical vascular cognitive impairment,” Journal of the Neurological Sciences, vol. 373, pp. 1–6, 2017. View at Publisher · View at Google Scholar
  • Mario Mascalchi, Emilia Salvadori, Nicola Toschi, Marco Giannelli, Stefano Orsolini, Stefano Ciulli, Andrea Ginestroni, Anna Poggesi, Antonio Giorgio, Francesca Lorenzini, Marco Pasi, Nicola De Stefano, Leonardo Pantoni, Domenico Inzitari, and Stefano Diciotti, “DTI-derived indexes of brain WM correlate with cognitive performance in vascular MCI and small-vessel disease. A TBSS study,” Brain Imaging and Behavior, 2018. View at Publisher · View at Google Scholar
  • Emilia Salvadori, Anna Poggesi, Giovanni Pracucci, Alberto Chiti, Laura Ciolli, Mirco Cosottini, Alessandra Del Bene, Nicola De Stefano, Stefano Diciotti, Ilaria Di Donato, Andrea Ginestroni, Sandro Marini, Mario Mascalchi, Serena Nannucci, Giovanni Orlandi, Marco Pasi, Francesca Pescini, Raffaella Valenti, Antonio Federico, Maria Teresa Dotti, Ubaldo Bonuccelli, Domenico Inzitari, and Leonardo Pantoni, “Application of the DSM-5 Criteria for Major Neurocognitive Disorder to Vascular MCI Patients,” Dementia and Geriatric Cognitive Disorders Extra, vol. 8, no. 1, pp. 104–116, 2018. View at Publisher · View at Google Scholar
  • Emilia Salvadori, Francesca Dieci, Paolo Caffarra, and Leonardo Pantoni, “Qualitative Evaluation of the Immediate Copy of the Rey–Osterrieth Complex Figure: Comparison Between Vascular and Degenerative MCI Patients,” Archives of Clinical Neuropsychology, 2018. View at Publisher · View at Google Scholar