Table of Contents Author Guidelines Submit a Manuscript
International Journal of Alzheimer’s Disease
Volume 2012, Article ID 649456, 5 pages
http://dx.doi.org/10.1155/2012/649456
Review Article

Analyzing Microarray Data of Alzheimer's Using Cluster Analysis to Identify the Biomarker Genes

1Department of Biotechnology, Al-Ameer College of Engineering & IT, Andhra Pradesh, Visakhapatnam 531173, India
2Jawaharlal Nehru Technological University, Andhra Pradesh, Kakinada 533003, India
3Endocrine & Diabetes Centre, Andhra Pradesh, Visakhapatnam 530002, India

Received 30 August 2011; Revised 11 November 2011; Accepted 28 November 2011

Academic Editor: Michal Novák

Copyright © 2012 Satya vani Guttula et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. G. Rogaeva, “Alzheimer's disease: genetic factors,” in The Encyclopedia of Aging, Springer, New York, NY, USA, 4th edition, 2006. View at Google Scholar
  2. M. Hutton, C. L. Lendon, P. Rizzu et al., “Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17,” Nature, vol. 393, no. 6686, pp. 702–704, 1998. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Goate, M. C. Chartier-Harlin, M. Mullan et al., “Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease,” Nature, vol. 349, no. 6311, pp. 704–706, 1991. View at Publisher · View at Google Scholar · View at Scopus
  4. R. Sherrington, E. I. Rogaev, Y. Liang et al., “Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease,” Nature, vol. 375, no. 6534, pp. 754–760, 1995. View at Google Scholar · View at Scopus
  5. E. I. Rogaev, R. Sherrington, E. A. Rogaeva et al., “Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene,” Nature, vol. 376, no. 6543, pp. 775–778, 1995. View at Google Scholar · View at Scopus
  6. R. J. Guerreiro, M. Baquero, R. Blesa et al., “Genetic screening of Alzheimer's disease genes in Iberian and African samples yields novel mutations in presenilins and APP,” Neurobiology of Aging, vol. 31, no. 5, pp. 725–731, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. A. M. Saunders, W. J. Strittmatter, D. Schmechel et al., “Association of apolipoprotein E allele ε4 with late-onset familial and sporadic Alzheimer's disease,” Neurology, vol. 43, no. 8, pp. 1467–1472, 1993. View at Google Scholar · View at Scopus
  8. M. B. Eisen, P. T. Spellman, P. O. Brown, and D. Botstein, “Cluster analysis and display of genome-wide expression patterns,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 25, pp. 14863–14868, 1998. View at Publisher · View at Google Scholar · View at Scopus
  9. W. Kong, X. Mou, Q. Liu et al., “Independent component analysis of Alzheimer's DNA microarray gene expression data,” Molecular Neurodegeneration, vol. 4, no. 1, article 4, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. C. R. Scherzer, K. Offe, M. Gearing et al., “Loss of apolipoprotein E receptor LR11 in Alzheimer disease,” Archives of Neurology, vol. 61, no. 8, pp. 1200–1205, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Ullrich, A. Münch, S. Neumann, E. Kremmer, J. Tatzelt, and S. F. Lichtenthaler, “The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein,” Journal of Biological Chemistry, vol. 285, no. 27, pp. 20664–20674, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. W. Chadwick, R. Brenneman, B. Martin, and S. Maudsley, “Complex and multidimensional lipid raft alterations in a murine model of Alzheimer's disease,” International Journal of Alzheimer's Disease, vol. 2010, Article ID 604792, 56 pages, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Tong, M. Dong, and S. M. De La Monte, “Brain insulin-like growth factor and neurotrophin resistance in parkinson's disease and dementia with lewy bodies: potential role of manganese neurotoxicity,” Journal of Alzheimer's Disease, vol. 16, no. 3, pp. 585–599, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. M. A. Garcia-Blanco, A. P. Baraniak, and E. L. Lasda, “Alternative splicing in disease and therapy,” Nature Biotechnology, vol. 22, no. 5, pp. 535–546, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. F. Hattori, N. Murayama, T. Noshita, and S. Oikawa, “Mitochondrial peroxiredoxin-3 protects hippocampal neurons from excitotoxic injury in vivo,” Journal of Neurochemistry, vol. 86, no. 4, pp. 860–868, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. R. C. Von Rotz, S. Kins, R. Hipfel, H. Von Der Kammer, and R. M. Nitsch, “The novel cytosolic RING finger protein dactylidin is up-regulated in brains of patients with Alzheimer's disease,” European Journal of Neuroscience, vol. 21, no. 5, pp. 1289–1298, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. I. Coronado-Pons, A. Novials, S. Casas, A. Clark, and R. Gomis, “Identification of iduronate-2-sulfatase in mouse pancreatic islets,” American Journal of Physiology, vol. 287, no. 5, pp. E983–E990, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Nalbantoglu, G. Karpati, and S. Carpenter, “Conspicuous accumulation of a single-stranded DNA binding protein in skeletal muscle fibers in inclusion body myositis,” American Journal of Pathology, vol. 144, no. 5, pp. 874–882, 1994. View at Google Scholar · View at Scopus
  19. A. J. George, L. Gordon, T. Beissbarth et al., “A serial analysis of gene expression profile of the Alzheimer's disease Tg2576 mouse model,” Neurotoxicity Research, vol. 17, no. 4, pp. 360–379, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. J. W. Pridgeon, T. Geetha, and M. W. Wooten, “A method to identify p62's UBA domain interacting proteins,” Biological Procedures Online, vol. 5, no. 1, pp. 228–237, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. C. Prinzen, D. Trümbach, W. Wurst, K. Endres, R. Postina, and F. Fahrenholz, “Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice,” BMC Genomics, vol. 10, article 66, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. P. R. Hof and J. H. Morrison, “Neocortical neuronal subpopulations labeled by a monoclonal antibody to calbindin exhibit differential vulnerability in Alzheimer's disease,” Experimental Neurology, vol. 111, no. 3, pp. 293–301, 1991. View at Publisher · View at Google Scholar · View at Scopus
  23. N.-H. Myung, X. Zhu, I. I. Kruman et al., “Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes,” Age, vol. 30, no. 4, pp. 209–215, 2008. View at Publisher · View at Google Scholar
  24. W. Cao, H. J. Song, T. Gangi et al., “Identification of novel genes that modify phenotypes induced by Alzheimer's β-amyloid overexpression in Drosophila,” Genetics, vol. 178, no. 3, pp. 1457–1471, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. T. Tondreau, M. Dejeneffe, N. Meuleman et al., “Gene expression pattern of functional neuronal cells derived from human bone marrow mesenchymal stromal cells,” BMC Genomics, vol. 9, article 166, 2008. View at Publisher · View at Google Scholar · View at Scopus