Dementia and Diabetes Mellitus: Association with Apolipoprotein E4 Polymorphism from a Hospital in Southern India
Table 1
Clinical profile and ApoE polymorphism in the study population.
Alzheimer’s dementia (AD) ()
Non-Alzheimer’s dementia (nAD) ()
Individuals with parental history of AD (f/hAD) ()
Control individuals with no parental history of dementia (NC) ()
P value (comparing AD and NC)
P value (comparing nAD and NC)
Mean age in years
0.56++
0.41++
M : F
105 : 104
75 : 47
51 : 19
114 : 79
0.076*
0.67*
DM, (%)
37 (17.7)
17 (13.9)
3 (4.3)
12 (6.2)
0.0004
*
0.02
*
HMSE
<0.0001 ++
<0.0001 ++
EASI
0
0
<0.0001 ++
<0.0001 ++
E2E2, (%)
0 (0)
1 (0.8)
0 (0)
0 (0)
1+
0.39+
E2E3, (%)
11 (5.3)
11 (9)
5 (7.1)
23 (11.9)
0.017
*
0.42*
E3E3, (%)
100 (47.8)
82 (67.2)
48 (68.6)
138 (71.5)
<0.0001
*
0.42*
E2E4, (%)
13 (6.2)
4 (3.3)
0 (0)
2 (1)
0.007 +
0.21+
E3E4, (%)
71 (34)
22 (18)
16 (22.9)
30 (15.5)
<0.0001
*
0.56*
E4E4, (%)
14 (6.7)
2 (1.6)
1 (1.4)
0 (0)
0.0001 +
0.15+
Total ApoE4 carrier, (%)
98 (46.9)
28 (23)
17 (24.3)
32 (16.6)
<0.0001
*
0.16*
ApoE4 carrier with DM, (%)
20 (9.6)
4 (3.3)
0 (0)
2 (1)
0.0001 +
0.21+
HMSE: Hindi Mental Status Examination (indicates level of cognitive function; highest score possible = 31). EASI: Everyday Abilities Scale for India (indicates level of functional disability, highest score possible = 12). P values calculated by unpaired t-test++, chi-square test*, and Fisher’s exact test+.
