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International Journal of Alzheimer’s Disease
Volume 2012, Article ID 703871, 6 pages
http://dx.doi.org/10.1155/2012/703871
Research Article

The Relation between Inflammation and Neuropsychological Test Performance

1Psychology Service, South Texas Veterans Healthcare System, San Antonio, TX 78229, USA
2Department of Psychiatry & Behavioral Health, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
3Department of Pharmacology & Neurosicence, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
4Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
5Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
6Department of Internal Medicine, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
7Institute for Aging and Alzheimer's Disease Research, University of North Texas Health Sciences Center, Fort Worth, TX 76107, USA

Received 19 April 2012; Revised 25 July 2012; Accepted 3 August 2012

Academic Editor: Christoph Laske

Copyright © 2012 Valerie H. Balldin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Considerable research documents an association between pro- and anti-inflammatory markers and Alzheimer's disease (AD), yet the differential relation between these markers and neuropsychological functioning in AD and nondemented controls has received less attention. The current study sought to evaluate the relationship between peripheral markers of inflammation (both pro- and anti-inflammatory) and neuropsychological functioning through the Texas Alzheimer's Research and Care Consortium (TARCC) cohort. Methods. There were 320 participants (Probable AD n=124, Controls n=196) in the TARCC Longitudinal Research Cohort available for analysis. Regression analyses were utilized to examine the relation between proinflammatory and anti-inflammatory markers and neuropsychological functioning. Follow-up analyses were conducted separately by case versus control status. Results. Proinflammatory and anti-inflammatory markers were found to be associated with neuropsychological testing. Third tertile proinflammatory markers were negatively associated with measures of attention and language, and anti-inflammatory markers were positively associated with measures of immediate verbal memory and delayed verbal and visual memory. Conclusions. These findings support the link between peripheral inflammatory markers and neuropsychological functioning and suggest the utility of examining profiles of inflammatory markers in the future.