A Unifying Hypothesis for Familial and Sporadic Alzheimer's Disease
Figure 2
Simulation output for model with high aggregation rates and normal Aβ clearance. Three different individual simulations are shown. The plots in each column are from the same simulation. (a)–(c) Levels of p53 (total pool including bound and ubiquitinated species). (e,f) p53 bound to GSK3β (GSK3b_p53), damaged DNA (damDNA), tau tangles, and Aβ plaques are shown.
