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International Journal of Alzheimer’s Disease
Volume 2013, Article ID 285462, 7 pages
Research Article

Utility of the Mini-Cog for Detection of Cognitive Impairment in Primary Care: Data from Two Spanish Studies

1Neurology Service, Virgen de las Nieves University Hospital, Granada, Spain
2FIDYAN Neurocenter, Granada, Spain
3Neurology Service, Infanta Leonor Hospital, Madrid, Spain
4Neurology Service, La Mancha Centro Hospital, Alcázar de San Juan, Spain
5Hermanos Sangro Specialties Clinic, Neurology Service, Gregorio Marañón General University Hospital, Madrid, Spain
6Alzheimer Disease Research Unit, Alzheimer Center Reina Sofia Foundation-CIEN Foundation, Carlos III Institute of Health, Madrid, Spain

Received 29 April 2013; Revised 16 July 2013; Accepted 19 July 2013

Academic Editor: Jesús Avila

Copyright © 2013 Cristóbal Carnero-Pardo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. To study the utility of the Mini-Cog test for detection of patients with cognitive impairment (CI) in primary care (PC). Methods. We pooled data from two phase III studies conducted in Spain. Patients with complaints or suspicion of CI were consecutively recruited by PC physicians. The cognitive diagnosis was performed by an expert neurologist, after formal neuropsychological evaluation. The Mini-Cog score was calculated post hoc, and its diagnostic utility was evaluated and compared with the utility of the Mini-Mental State (MMS), the Clock Drawing Test (CDT), and the sum of the MMS and the CDT ( ) using the area under the receiver operating characteristic curve (AUC). The best cut points were obtained on the basis of diagnostic accuracy (DA) and kappa index. Results. A total sample of 307 subjects (176 CI) was analyzed. The Mini-Cog displayed an AUC (±SE) of , which was significantly inferior to the AUC of the CDT ( ), the MMS ( ), and the ( ). The best cut point of the Mini-Cog was 1/2 (sensitivity 0.60, specificity 0.90, DA 0.73, and kappa index ). Conclusions. The utility of the Mini-Cog for detection of CI in PC was very modest, clearly inferior to the MMS or the CDT. These results do not permit recommendation of the Mini-Cog in PC.